
Pachlopnik Lab.
Understanding
Primary Immunodeficiencies
ABOUT.
Our lab focuses on inborn errors of the immune system and their consequences on health - often an increased susceptibility to infections or an immune dysregulation. Many severe forms of immune defects affect babies and children when coming into first contact with pathogens. Treatment of patients is very dependent on the type of immune defect. We focus on patients, in whom routine diagnosis does not find the cause of the disease or disease cause is not well understood.
We have established a joint genomic and transcriptomic workflow, combined with thorough functional and phenotypical examinations of leukocytes and fibroblasts from patients with extreme immunological phenotypes. Analyses of these datasets in combination with functional validation in animal models enabled us to identify novel diseases to better characterize pathomechanisms of known inborn error of immunity and to apply targeted treatments.
OUR RESEARCH.
We are interested in studying disease mechanisms.
Our goal is to broaden the knowledge of human immunology and improve treatment for patients with immune diseases.
OUR TEAM.
Sonja
Brun
Study Nurse
Sonja
Brun
Esther
Gujer
MMed Student
Esther
Gujer
Michael
Killian
MMed Student
Michael
Killian
Katri
Eskola
Study Nurse
Katri
Eskola
Seraina
Prader
MD
Medical Doctor
Seraina
Prader
MD
LATEST PUBLICATIONS.
November 2020
IMMUNOLOGICAL ASSESMENT OF PEDIATRIC MULTIYSTEM INFLAMMATORY SYNDROME RELATED TO CORONAVIRUS DISEASE 2019
April 2020
ERYTHROPOIESIS DEFECT OBSERVED IN STAT3 GOF PATIENTS WITH SEVERE ANEMIA
Mauracher AA, Eekels JJM, Woytschak J, van Drogen A, Bosch A, Prader S, Felber M, Heeg M, Opitz L, Trück J, Schroeder S, Adank E, Klocperk A, Haralambieva E, Zimmermann D, Tantou S, Kotsonis K, Stergiou A, Kanariou MG, Ehl S, Boyman O, Sediva A, Renella R, Schmugge M, Vavassori S, Pachlopnik Schmid J.
J Allergy Clin Immunol.
January 2019
EPITHELIAL PROLIFERATION IN INFLAMMATORY SKIN DISEASE IS REGULATED BY TTC7 IN FIBROBLASTS AND LYMPHOCYTES
December 2018
January 2018
CLASSIFICATION, CLINICAL MANIFESTATION AND DIAGNOSIS OF HLH
Pachlopnik Schmid J, Volkmer B, Ehl S. Histiocytic Disorders.
COLLABORATIONS.
FUNDS.
HOW TO FIND US.
ADDRESS: AUGUST FOREL STRASSE 7, 8008 ZURICH, SWITZERLAND
TEL: +41 44 635 29 31 | Immuno.Forschung@kispi.uzh.ch